| 1 | 03 April 1988 | Autódromo Internacional Nelson Piquet | Brazilian Grand Prix | Alain Prost | McLaren | 60 | 1:36:06.857 |
| 2 | 01 May 1988 | Autodromo Enzo e Dino Ferrari | San Marino Grand Prix | Ayrton Senna | McLaren | 60 | 1:32:41.264 |
| 3 | 15 May 1988 | Circuit de Monaco | Monaco Grand Prix | Alain Prost | McLaren | 78 | 1:57:17.077 |
| 4 | 29 May 1988 | Autódromo Hermanos Rodríguez | Mexican Grand Prix | Alain Prost | McLaren | 67 | 1:30:15.737 |
| 5 | 12 June 1988 | Circuit Gilles Villeneuve | Canadian Grand Prix | Ayrton Senna | McLaren | 69 | 1:39:46.618 |
| 6 | 19 June 1988 | Detroit Street Circuit | Detroit Grand Prix | Ayrton Senna | McLaren | 63 | 1:54:56.035 |
| 7 | 03 July 1988 | Circuit Paul Ricard | French Grand Prix | Alain Prost | McLaren | 80 | 1:37:37.328 |
| 8 | 10 July 1988 | Silverstone Circuit | British Grand Prix | Ayrton Senna | McLaren | 65 | 1:33:16.367 |
| 9 | 24 July 1988 | Hockenheimring | German Grand Prix | Ayrton Senna | McLaren | 44 | 1:32:54.188 |
| 10 | 07 August 1988 | Hungaroring | Hungarian Grand Prix | Ayrton Senna | McLaren | 76 | 1:57:47.081 |
| 11 | 28 August 1988 | Circuit de Spa-Francorchamps | Belgian Grand Prix | Ayrton Senna | McLaren | 43 | 1:28:00.549 |
| 12 | 11 September 1988 | Autodromo Nazionale di Monza | Italian Grand Prix | Gerhard Berger | Ferrari | 51 | 1:17:39.744 |
| 13 | 25 September 1988 | Autódromo do Estoril | Portuguese Grand Prix | Alain Prost | McLaren | 70 | 1:37:40.958 |
| 14 | 02 October 1988 | Circuito de Jerez | Spanish Grand Prix | Alain Prost | McLaren | 72 | 1:48:43.851 |
| 15 | 30 October 1988 | Suzuka Circuit | Japanese Grand Prix | Ayrton Senna | McLaren | 51 | 1:33:26.173 |
| 16 | 13 November 1988 | Adelaide Street Circuit | Australian Grand Prix | Alain Prost | McLaren | 82 | 1:53:14.676 |